Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review.
Yue LiRuishuang MaXia HaoPublished in: Cell death & disease (2024)
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) represents the initial tumor suppressor gene identified to possess phosphatase activity, governing various cellular processes including cell cycle regulation, migration, metabolic pathways, autophagy, oxidative stress response, and cellular senescence. Current evidence suggests that PTEN is critical for stem cell maintenance, self-renewal, migration, lineage commitment, and differentiation. Based on the latest available evidence, we provide a comprehensive overview of the mechanisms by which PTEN regulates activities of different stem cell populations and influences neurological disorders, encompassing autism, stroke, spinal cord injury, traumatic brain injury, Alzheimer's disease and Parkinson's disease. This review aims to elucidate the therapeutic impacts and mechanisms of PTEN in relation to neurogenesis or the stem cell niche across a range of neurological disorders, offering a foundation for innovative therapeutic approaches aimed at tissue repair and regeneration in neurological disorders. This review unravels novel therapeutic strategies for tissue restoration and regeneration in neurological disorders based on the regulatory mechanisms of PTEN on neurogenesis and the stem cell niche.
Keyphrases
- stem cells
- cell proliferation
- pi k akt
- cell cycle
- cerebral ischemia
- traumatic brain injury
- spinal cord injury
- signaling pathway
- cell therapy
- cell death
- spinal cord
- dna damage
- oxidative stress
- genome wide
- dna methylation
- endoplasmic reticulum stress
- subarachnoid hemorrhage
- intellectual disability
- brain injury
- endothelial cells
- copy number
- mesenchymal stem cells
- transcription factor
- cognitive decline
- bone marrow