Synthesis of antimicrobial azoloazines and molecular docking for inhibiting COVID-19.
Zeinab A MuhammadThoraya A FarghalyIsmail AlthagafiSami A Al-HussainMagdi E A ZakiMarwa F HarrasPublished in: Journal of heterocyclic chemistry (2021)
Diverse new azoloazines were synthesized from the reaction of fluorinated hydrazonoyl chlorides with heterocyclic thiones, 1,8-diaminonaphthalene, ketene aminal derivatives, and 4-amino-5-triflouromethyl-1,2,4-triazole-2-thiol. The mechanistic pathways and the structures of all synthesized derivatives were discussed and assured based on the available spectral data. The synthesized azoloazine derivatives were evaluated for their antifungal and antibacterial activities through zone of inhibition measurement. The results revealed promising antifungal activities for compounds 4, 5, 17a,b, 19, and 25 against the pathogenic fungal strains used; Aspergillus flavus and Candida albicans compared to ketoconazole. In addition, compounds 4, 5, 19, and 25 showed moderate antibacterial activities against most tested bacterial strains. Molecular docking studies of the promising compounds were carried out on leucyl-tRNA synthetase active site of Candida albicans, suggesting good binding in the active site forming stable complexes. Moreover, docking of the synthesized compounds was performed on the active site of SARS-CoV-2 3CLpro to predict their potential as a hopeful anti-COVID and to investigate their binding pattern.
Keyphrases
- candida albicans
- molecular docking
- sars cov
- molecular dynamics simulations
- biofilm formation
- coronavirus disease
- escherichia coli
- respiratory syndrome coronavirus
- signaling pathway
- magnetic resonance imaging
- high resolution
- optical coherence tomography
- structure activity relationship
- electronic health record
- binding protein
- computed tomography
- high intensity
- single cell
- climate change
- mass spectrometry
- essential oil