Mutational basis of serum cross-neutralization profiles elicited by infection or vaccination with SARS-CoV-2 variants.

Kshitij Wagh Xiaoying X Shen James TheilerBethany GirardJean-Claude MarshallDavid C MontefioriBette Korber

Published in: bioRxiv : the preprint server for biology (2023)

Modeled SARS-CoV-2 cross-neutralization using mutations at key sitesIdentified resistance mutations and quantified relative impactAccurately predicted holdout variant and convalescent/vaccine sera neutralizationShowed that the third dose of mRNA-1273 vaccination overcomes resistance mutations.

Keyphrases

sars cov
respiratory syndrome coronavirus
copy number
dna methylation