Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is associated with IRF7, BANK1 and TBX21 polymorphisms in two populations.
Yaqing ShuJ GuoX MaY YanY WangC ChenX SunHonghao WangJ YinY LongX YanZhengqi LuF PetersenX YuWei QiuPublished in: European journal of neurology (2020)
The present study has for the first time identified non-HLA susceptibility genes for anti-NMDAR encephalitis. The association of IRF7, BANK1 and TBX21 with anti-NMDAR encephalitis suggests that B-cell activation, Th1 responses, virus infection and the type I interferon signaling pathway are involved in the pathogenesis of the disease.