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FOXO3 regulates a common genomic program in aging and glioblastoma stem cells.

Amanda J AudesseGalina KarashchukZachary A GardellNelli S LakisSun Y Maybury-LewisAbigail K BrownDena S LeemanYee Voan TeoNicola NerettiDouglas C AnthonyAlexander S BrodskyAshley E Webb
Published in: Aging and cancer (2021)
This work identifies a FOXO-associated transcriptional program that correlates between GSCs and aging NSCs and is enriched for metabolic and stemness pathways connected with GBM and aging.
Keyphrases
  • stem cells
  • transcription factor
  • quality improvement
  • signaling pathway
  • pi k akt
  • epithelial mesenchymal transition
  • genome wide
  • copy number
  • cell therapy
  • cell proliferation
  • heat shock