FOXO3 regulates a common genomic program in aging and glioblastoma stem cells.

Amanda J AudesseGalina KarashchukZachary A GardellNelli S LakisSun Y Maybury-LewisAbigail K BrownDena S LeemanYee Voan TeoNicola NerettiDouglas C AnthonyAlexander S BrodskyAshley E Webb

Published in: Aging and cancer (2021)

This work identifies a FOXO-associated transcriptional program that correlates between GSCs and aging NSCs and is enriched for metabolic and stemness pathways connected with GBM and aging.

Keyphrases

stem cells
transcription factor
quality improvement
signaling pathway
pi k akt
epithelial mesenchymal transition
genome wide
copy number
cell therapy
cell proliferation
heat shock