TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma.

Nur P Damayanti Ricardo A Cordova Christopher Rupert Ilaria Delle Fontane Li Shen Sabrina Orsi Angela J Klunk W Marston Linehan Kirk A Staschke Peter C Hollenhorst David E Heppner Roberto Pili

Published in: Cancer research (2024)

TFE3-splicing factor fusions possess both transcription and splicing factor functions that remodel the transcriptome and spliceosome and can be targeted with dimerization inhibitors to suppress the growth of translocation renal cell carcinoma.

Keyphrases

renal cell carcinoma
gene expression
transcription factor
genome wide
rna seq
single cell
cancer therapy
drug delivery