Efficacy and safety of corticosteroids in cardiac arrest: a systematic review, meta-analysis and trial sequential analysis of randomized control trials.
Jeremy PennWill DouglasJeffrey CurranDipayan ChaudhuriJoanna C DionneShannon M FernandoDavid GrantonRebecca MathewBram RochwergPublished in: Critical care (London, England) (2023)
In patients during or after cardiac arrest, corticosteroids have an uncertain effect on mortality but probably increase ROSC and may increase the likelihood of survival with good functional outcome at hospital discharge. Corticosteroids may decrease ventilator associated pneumonia, may increase renal failure, and have an uncertain effect on bleeding and peritonitis. However, the pooled evidence examining these outcomes was sparse and imprecision contributed to low or very low certainty of evidence.
Keyphrases
- cardiac arrest
- phase iii
- cardiopulmonary resuscitation
- systematic review
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- open label
- phase ii
- double blind
- clinical trial
- peritoneal dialysis
- study protocol
- atrial fibrillation
- prognostic factors
- cardiovascular events
- risk factors
- coronary artery disease
- placebo controlled
- skeletal muscle
- patient reported outcomes
- meta analyses