Caspase-8 Promotes Pulmonary Hypertension by Activating Macrophage-Associated Inflammation and IL-1β (Interleukin 1β) Production.

Wuwei Rong Chenchen LiuXiaoming LiNaifu WanLijiang WeiWentong ZhuPei-Yuan BaiMing LiYangjing OuFang LiLingxia WangXuanhui WuJianling LiuMingyan XingXiaoming ZhaoHan LiuHaibing ZhangAnkang Lyu

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

Taken together, our study suggests that macrophage-derived IL-1β via caspase-8-dependent canonical inflammasome is required for macrophages to play a pathogenic role in pulmonary perivascular inflammation.

Keyphrases

pulmonary hypertension
oxidative stress
cell death
induced apoptosis
adipose tissue
pulmonary artery
pulmonary arterial hypertension
signaling pathway
endoplasmic reticulum stress