Simultaneous Electrophysiology and Optogenetic Perturbation of the Same Neurons in Chronically Implanted Animals using μLED Silicon Probes.

This method allows a researcher to simultaneously perturb neural activity and record electrophysiological signal from the same neurons with high spatial specificity using silicon probes with integrated μLEDs. We outline a procedure detailing all stages of the process for performing reliable μLED experiments in chronically implanted rodents.