Impact of prior systemic therapy on lymphocytic infiltration in surgically resected breast cancer brain metastases.

S Chew MinminA BacottiY ChenC AndersM SambadeA M DealD TrembathM J McKeeE BrogiAndrew D Seidman

Published in: Breast cancer research and treatment (2023)

This observation suggests that systemic therapy may interfere with the immune response to BCBMs and cause exhaustion of anti-tumor immunity. This motivates clinical investigation of strategies to enhance LI for therapeutic benefit to improve outcomes for patients with BCBMs.

Keyphrases

brain metastases
small cell lung cancer
lymph node
stem cells
metabolic syndrome
mesenchymal stem cells
adipose tissue
ion batteries