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Activation of the JAK/STAT Pathway Leads to BRAF Inhibitor Resistance in BRAFV600E Positive Thyroid Carcinoma.

Jessica LimbergCaitlin E EganKatherine D GrayMandeep SinghZachary LoewensteinYanping YangMaria Cristina RiascosHala Al AsadiParima SafeSteve El EshakyHeng LiangTimothy M UllmannWeibin WangWei LiTuo ZhangJenny Zhaoying XiangDessislava StefanovaMoonsoo M JinRasa ZarnegarThomas J FaheyIrene M Min
Published in: Molecular cancer research : MCR (2023)
Dual inhibition of BRAF and JAK/STAT signaling pathway is a potential therapeutic treatment for anticancer activity and to overcome drug resistance to BRAFi in thyroid cancer.
Keyphrases
  • signaling pathway
  • metastatic colorectal cancer
  • wild type
  • pi k akt
  • epithelial mesenchymal transition
  • combination therapy
  • induced apoptosis
  • endoplasmic reticulum stress