Activation of the JAK/STAT Pathway Leads to BRAF Inhibitor Resistance in BRAFV600E Positive Thyroid Carcinoma.

Jessica Limberg Caitlin E Egan Katherine D Gray Mandeep Singh Zachary Loewenstein Yanping Yang Maria Cristina Riascos Hala Al Asadi Parima Safe Steve El Eshaky Heng Liang Timothy M Ullmann Weibin Wang Wei Li Tuo Zhang Jenny Zhaoying Xiang Dessislava Stefanova Moonsoo M Jin Rasa Zarnegar Thomas J Fahey Irene M Min

Published in: Molecular cancer research : MCR (2023)

Dual inhibition of BRAF and JAK/STAT signaling pathway is a potential therapeutic treatment for anticancer activity and to overcome drug resistance to BRAFi in thyroid cancer.

Keyphrases

signaling pathway
metastatic colorectal cancer

wild type
pi k akt

epithelial mesenchymal transition
combination therapy

induced apoptosis
endoplasmic reticulum stress