DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus.

Juliana Imgenberg-KreuzJonas Carlsson AlmlöfDag LeonardAndrei AlexssonGunnel NordmarkMaija-Leena ElorantaSolbritt Rantapää-DahlqvistAnders A BengtssonAndreas JönsenLeonid PadyukovIva GunnarssonElisabet SvenungssonChristopher SjöwallLars RönnblomAnn-Christine SyvänenJohanna K Sandling

Published in: Annals of the rheumatic diseases (2018)

Our results suggest that several of the genetic risk variants for SLE may exert their influence on the phenotype through alteration of DNA methylation levels at regulatory regions of target genes.

Keyphrases

genome wide
dna methylation
copy number
systemic lupus erythematosus
gene expression
transcription factor
disease activity
rheumatoid arthritis