Cognitive impairment in early MS: contribution of white matter lesions, deep grey matter atrophy, and cortical atrophy.

Christina EnglLaura Tiemann Sophia Grahl Matthias BussasPaul SchmidtViola PongratzAchim BertheleAnnkathrin BeerChristian Gaser Jan Stefan Kirschke Claus Zimmer Bernhard Hemmer Mark Mühlau

Published in: Journal of neurology (2020)

Although several mechanisms contribute to CI already in the early stage of MS, WML seem to be the main driver with thalamic atrophy primarily intensifying this effect.

Keyphrases

white matter
multiple sclerosis
early stage
cognitive impairment
mass spectrometry
ms ms
radiation therapy
sentinel lymph node