CCL5 promotes the epithelial-mesenchymal transition of circulating tumor cells in renal cancer.

Yibing GuanXueyi LiuJuanhua TianGuang YangFangshi XuNi GuoLingyu GuoZiyan WanZhixin HuangMei GaoTie Chong

Published in: Journal of translational medicine (2024)

In summary, CCL5 promoted EMT in renal cancer cells and CTCs through smad2/3, enhancing the malignant phenotype and facilitating lung metastasis. Mesenchymal-type CTC-related factors can construct a risk model for renal cancer patients, allowing personalized treatment based on metastatic risk prediction.

Keyphrases

circulating tumor cells
epithelial mesenchymal transition
transforming growth factor
circulating tumor
signaling pathway
squamous cell carcinoma
stem cells
small cell lung cancer
papillary thyroid
bone marrow
liver injury
squamous cell
young adults
combination therapy