Corneal Subbasal Nerve Plexus Changes in Severe Diabetic Charcot Foot Deformity: A Pilot Study in Search for a DNOAP Biomarker.

Anica HerlynRuby Kala PrakasamSabine PeschelStephan AllgeierBernd KöhlerKarsten WinterRudolf F GuthoffThomas MittlmeierOliver Stachs

Published in: Journal of diabetes research (2018)

This pilot study revealed a rarefication of SNP in all measured parameters in patients with severe DNOAP. We see a potential value of CCM providing a SNP-based biomarker for early stages of DNOAP prior to the development of any foot deformities that needs to be evaluated in further studies. This trial is registered with German Clinical Trials Register (DKRS) DRKS00007537.

Keyphrases

clinical trial
genome wide
early onset
phase ii
wound healing
phase iii
type diabetes
high density
study protocol
dna methylation
ultrasound guided
genetic diversity
gene expression
drug induced
risk assessment
human health
double blind