Spatial and Amplitude Dynamics of Neurostimulation: Insights from the Acute Intrahippocampal Kainate Seizure Mouse Model.

Thomas J Foutz Nicholas RensingLirong HanDominique M Durand Michael Wong

Published in: bioRxiv : the preprint server for biology (2023)

Evaluated spatial and temporal parameters of neurostimulation in a mouse model of acute seizuresBrief bursts of high-frequency (100 Hz) stimulation effectively interrupted epileptiform activity.The suppressive effect was highly dependent on stimulation amplitude and was maximal at the ipsilateral CA1 and CA3 regions.Pro-excitatory effects were identified with high-amplitude high-frequency stimulation at the ventral hippocampal commissure and contralateral CA1.

Keyphrases

high frequency
mouse model
transcranial magnetic stimulation
liver failure
resting state
respiratory failure
drug induced
aortic dissection
functional connectivity
protein kinase
spinal cord
heart rate
temporal lobe epilepsy
mechanical ventilation