The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [ 11 C]UCB-J.
Takuya ToyonagaNikkita KhattarYanjun WuYihuan LuMika NaganawaJean-Dominique GallezotDavid MatuskeyAdam P MeccaBrian PittmanMark DiasNabeel B NabulsiSjoerd J FinnemaMing-Kai ChenAmy ArnstenRajiv RadhakrishnanPatrick D SkosnikDeepak Cyril D'SouzaIrina EsterlisYiyun HuangChristopher H van DyckRichard E CarsonPublished in: European journal of nuclear medicine and molecular imaging (2023)
]C-UCB-J PET showed age-related decreases of gray matter volume, synaptic density, and blood flow; however, the regional patterns of the reductions in volume and SV2A binding were different. Those patterns suggest that MR-based measures of GM volume may not be directly representative of synaptic density.