Checkpoint Kinase 1 Stimulates Endogenous Cardiomyocyte Renewal and Cardiac Repair by Binding to Pyruvate Kinase Isoform M2 C-Domain and Activating Cardiac Metabolic Reprogramming in a Porcine Model of Myocardial Ischemia/Reperfusion Injury.

Tian-Wen WeiTian-Kai Shan Hao WangJia-Wen ChenTong-Tong YangLiu-Hua ZhouDi ZhaoJia-Teng SunSi-Bo WangLing-Feng GuChong DuQi-Qi JiangRui SunQi-Ming WangXiang-Qing KongXiao-Hu LuHao-Liang Sun Yi Xu Li-Ping XieAi-Hua GuFeng Chen Yong Ji Xue-Jiang Guo Lian-Sheng Wang

Published in: Journal of the American Heart Association (2024)

This study demonstrates that the 1-265 amino acid domain of CHK1 binds to the 157-400 domain of PKM2 and activates PKM2-mediated metabolic reprogramming to promote cardiomyocyte proliferation and myocardial repair after ischemia/reperfusion injury in adult pigs.

Keyphrases

left ventricular
ischemia reperfusion injury
amino acid
signaling pathway
angiotensin ii
dna damage
protein kinase
tyrosine kinase
oxidative stress
heart failure
cell cycle
cell proliferation
high glucose
dna damage response