Untargeted metabolomics reveals a mild impact of remote ischemic conditioning on the plasma metabolome and α-hydroxybutyrate as a possible cardioprotective factor and biomarker of tissue ischemia.
Mia Roest LaursenJakob HansenCasper ElkjærNinna StavnagerCamilla Bak NielsenKasper PrydsJacob JohnsenJan Møller NielsenHans Erik BøtkerMogens JohannsenPublished in: Metabolomics : Official journal of the Metabolomic Society (2017)
Untargeted metabolomics analysis of plasma following RIC has led to insight into metabolism during RIC and revealed a possible novel metabolite of relevance to ischemic-reperfusion damage.
Keyphrases
- mass spectrometry
- cerebral ischemia
- liquid chromatography
- ischemia reperfusion injury
- gas chromatography mass spectrometry
- gas chromatography
- acute myocardial infarction
- oxidative stress
- high resolution
- subarachnoid hemorrhage
- single cell
- blood brain barrier
- acute ischemic stroke
- coronary artery disease
- atrial fibrillation
- simultaneous determination
- tandem mass spectrometry