GLP-2 Acutely Prevents Endotoxin-Related Increased Intestinal Paracellular Permeability in Rats.

Koji MarutaTakeshi TakajoYasutada AkibaHyder SaidEmi IrieIkuo KatoAtsukazu KuwaharaJonathan D Kaunitz

Published in: Digestive diseases and sciences (2020)

Systemic LPS releases endogenous GLP-2, reducing LPS-related increased permeability. The therapeutic window of exogenous GLP-2 administration is at minimum within 6-12 h after LPS treatment. Exogenous GLP-2 treatment is of value in the prevention of increased paracellular permeability associated with endotoxemia.

Keyphrases

inflammatory response
endothelial cells
anti inflammatory
replacement therapy
drug induced
smoking cessation