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Concomitant dysregulation of the estrogen receptor and BRAF/MEK signaling pathways is common in colorectal cancer and predicts a worse prognosis.

Dingxie Liu
Published in: Cellular oncology (Dordrecht) (2019)
Combined activity of the ER and BRAF/MEK pathways may represent a novel biomarker for CRC prognosis and clinical management.
Keyphrases
  • estrogen receptor
  • pi k akt
  • signaling pathway
  • metastatic colorectal cancer
  • wild type
  • epithelial mesenchymal transition
  • breast cancer cells