Total synthesis of jamaicamide B.

Jamaicamide B was isolated from the cyanobacterium Moorea producens in Jamaica and shows neurotoxicity as a sodium channel blocker. This unique mixed peptide-polyketide structure contains a pyrrolinone ring, a β-methoxy enone, an ( E )-olefin, an undetermined stereocenter at C9, an ( E )-chloroolefin, and a terminal alkyne. We report herein the first total synthesis and structural confirmation of the marine natural product (9 S )-jamaicamide B.