A DNA adenine demethylase impairs PRC2-mediated repression of genes marked by a specific chromatin signature.

Qingxiao JiaXinran ZhangQian LiuJunjie LiWentao WangXuan MaBo ZhuSheng LiShicheng GongJingjing TianMeng YuanYu ZhaoDao-Xiu Zhou

Published in: Genome biology (2023)

Our findings unravel a function of ALKBH1 to control the balance between the antagonistic histone methylations for gene activity and provide insight into the regulatory mechanism of PRC2-mediated H3K27me3 deposition within the gene body region.

Keyphrases

genome wide
genome wide identification
transcription factor
dna methylation
copy number
gene expression
genome wide analysis
dna damage
circulating tumor
circulating tumor cells