The role of serum uric acid in the prediction of graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.

Katayoon GhasemiSayeh ParkhidehMohammad Hossein KazemiMaryam SalimiSina SalariRonak NaliniAbbas Hajifathali

Published in: Journal of clinical laboratory analysis (2020)

Our results indicated that serum UA levels lower than 3.4 mg/dL could significantly increase the incidence of GVHD and hazard of death. The antioxidant functions of UA could explain the lower incidence of GVHD in hyperuricemic patients. However, the inconsistencies of the previous studies require further investigation to elucidate the role of UA in the prediction of GVHD.

Keyphrases

allogeneic hematopoietic stem cell transplantation
uric acid
acute lymphoblastic leukemia
acute myeloid leukemia
end stage renal disease
metabolic syndrome
risk factors
ejection fraction
chronic kidney disease
newly diagnosed
oxidative stress
prognostic factors
anti inflammatory
patient reported