Increased autophagy/mitophagy levels in primary tumours of patients with pancreatic neuroendocrine neoplasms.

Kosmas DaskalakisKrystallenia I AlexandrakiIsmini KloukinaEvanthia KassiEvangelos FelekourasEvangelia XingiStamatis N PagakisApostolos V TsolakisEvangelos AndreakosGregory KaltsasKonstantinos Kambas

Published in: Endocrine (2020)

Increased autophagy levels are present in primary tumours of patients with PanNENs and are partially attributed to upregulated mitophagy. Grade was the only clinico-pathological parameter associated with autophagy scores.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
nlrp inflammasome