Identification of cysteine thiol-based linkages in ADAMTS13 in support of a non-proteolytic regulation of von Willebrand factor.

Hanspeter RottensteinerBirgit K SeyfriedStefan KaufmannChristian FiedlerJing-Fei DongX Long ZhengBarbara PlaimauerFriedrich Scheiflinger

Published in: Journal of thrombosis and haemostasis : JTH (2019)

Our results suggest that a dynamic network of free thiols in ADAMTS13 undergoing intra- and inter-molecular redox reactions may add another layer of regulation to VWF function under various conditions.

Keyphrases

living cells
single molecule
fluorescent probe
bioinformatics analysis
network analysis