Loss of Y in leukocytes as a risk factor for critical COVID-19 in men.

Bożena Bruhn-Olszewska Hanna Davies Daniil Sarkisyan Ulana Juhas Edyta Rychlicka-Buniowska Magdalena Wójcik Monika Horbacz Marcin Jakalski Pawel Olszewski Jakub Orzechowski WestholmAgata SmialowskaKarol Wierzba Åsa Torinsson NaluaiNiklas JernLars-Magnus Andersson Josef D Järhult Natalia Filipowicz Eva Tiensuu JansonSten RubertssonMiklos Lipcsey Magnus Gisslen Michael Hultström Robert Frithiof Jan P Dumanski

Published in: Genome medicine (2022)

We present a link between LOY and an acute, life-threatening infectious disease. Furthermore, this study highlights LOY as the most prominent clonal mutation affecting the myeloid cell lineage during emergency myelopoiesis. The correlation between LOY level and COVID-19 severity might suggest that this mutation affects the functions of monocytes and neutrophils, which could have consequences for male innate immunity.

Keyphrases

coronavirus disease
sars cov
infectious diseases
single cell
dendritic cells
peripheral blood
liver failure
emergency department
public health
bone marrow
cell therapy
respiratory syndrome coronavirus
drug induced
middle aged
immune response
intensive care unit
mesenchymal stem cells
hepatitis b virus
cell fate