LRP1 is a neuronal receptor for α-synuclein uptake and spread.

Kai ChenYuka A MartensAxel MenesesDaniel H RyuWenyan LuAna Caroline RaulinFuyao LiJing ZhaoYixing ChenYunjung JinCynthia LinaresMarshall GoodwinYonghe LiChia-Chen LiuTakahisa KanekiyoDavid M HoltzmanTodd E GoldeGuojun BuNa Zhao

Published in: Molecular neurodegeneration (2022)

We identified LRP1 as a key regulator of α-Syn neuronal uptake, as well as an important mediator of α-Syn spread in the brain. This study provides new knowledge on the physiological and pathological role of LRP1 in α-Syn trafficking and pathology, offering insight for the treatment of synucleinopathies.

Keyphrases

cerebral ischemia
healthcare
low density lipoprotein
transcription factor
resting state
blood brain barrier
binding protein