Exploring the Ferroptosis Mechanism of Zhilong Huoxue Tongyu Capsule for the Treatment of Intracerebral Hemorrhage Based on Network Pharmacology and In Vivo Validation.

Lixia Wang Wei Ren Wang LiLinshen MaoMaryam Mazhar Chen Zhou Houping Xu Sijin Yang

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

It is concluded that the ZL capsule could alleviate ICH in a muti-target and multi-pathway manner. ZL capsule could alleviate ICH by inhibiting ferroptosis, and TP53 is identified to be the potential target. Further research is needed to clarify the detailed anti-ferroptotic mechanism of the ZL capsule.

Keyphrases

cell death
signaling pathway
brain injury
risk assessment
human health
network analysis