Exploring the impact of acetylsalicylic acid and conditioned medium obtained from mesenchymal cells, individually and in combination, on cognitive function, histological changes, and oxidant-antioxidant balance in male rats with hippocampal injury.
Iman ZangiabadiMehran IlaghiAli ShamsaraSeyed Hassan Eftekhar-VaghefiMona SaheliMohammad ShabaniPublished in: Brain and behavior (2024)
The ability of ASA, CM obtained from adipose tissue-derived MSCs, and their combination therapy to alleviate hippocampal injuries highlights their promising therapeutic potential as a neuroprotection strategy against brain damage. Our findings provide preliminary evidence of the potential synergistic effects of ASA and CM, which warrants further investigations.
Keyphrases
- combination therapy
- cerebral ischemia
- adipose tissue
- induced apoptosis
- oxidative stress
- subarachnoid hemorrhage
- brain injury
- blood brain barrier
- cell cycle arrest
- mesenchymal stem cells
- anti inflammatory
- stem cells
- insulin resistance
- bone marrow
- high fat diet
- resting state
- endoplasmic reticulum stress
- cancer therapy
- umbilical cord
- skeletal muscle
- metabolic syndrome
- functional connectivity
- cell proliferation
- signaling pathway