Genetic Analysis of Obstructive Sleep Apnea and Its Relationship with Severe COVID-19.

Satu J StrauszElizabete AgafonovaVarvara TiullinenTuomo KiiskinenMartin BrobergSanni E RuotsalainenJukka KoskelaAdel BachourTamar SoferDaniel J GottliebAarno PalotieTuula PalotieSamuli RipattiHanna M Ollila

Published in: Annals of the American Thoracic Society (2024)

Our analysis identified novel genetic risk factors for OSA and showed that OSA is a causal risk factor for severe COVID-19. The effect is predominantly explained by higher BMI and suggests BMI-dependent effects at the level of individual variants and at the level of comorbid causality.

Keyphrases

obstructive sleep apnea
coronavirus disease
positive airway pressure
sars cov
body mass index
early onset
copy number
sleep apnea
weight gain
respiratory syndrome coronavirus
genome wide
drug induced
electronic health record
weight loss