GAL3 Mediates Vascular Dysfunction in Obesity by Regulating NOX1.
Caleb A PadgettRobert K BatoriAndrew C SpeeseCody L RosewaterWeston B BushCassandra C DerellaStephen B HaighHunter G SellersZachary L CorleyMadison A WestJames D MintzBrittany B AngeRyan A HarrisMichael W BrandsDavid J R FultonDavid W SteppPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
mice, likely through an NOX1-mediated mechanism. Pathological levels of GAL3, and in turn NOX1, are amenable to improvements in metabolic status, presenting a potential therapeutic target to ameliorate pathological cardiovascular consequences of obesity.