Single nucleotide variants in immune-response genes and the tumor microenvironment composition predict progression of mantle cell lymphoma.
Guilherme Rossi Assis de MendonçaAndré FattoriRafael Malagoli RochaGustavo Jacob LourençoMárcia Torresan DelamainSuely NonogakiVladmir Cláudio Cordeiro de LimaGisele Wally Braga ColleoniCármino Antonio de SouzaFernando Augusto SoaresCarmen Silvia Passos LimaJosé VassalloPublished in: BMC cancer (2021)
Our results indicate that the TME composition has relevant biological roles in MCL. In this setting, immunohistochemical detection of T-reg cells, IL17A and IL2, coupled with SNV genotyping in IL10, TGFBR2 and IL2, may represent novel prognostic factors in this disease, following future validations.