An Isoxazoloquinone Derivative Inhibits Tumor Growth by Targeting STAT3 and Triggering Its Ubiquitin-Dependent Degradation.

Yuanzhu XieShuaiwen ZhuLing ChenHongdou LiuTing PengZhengnan MingZizheng ZouXiyuan HuWensong LuoKunjian PengYuan NieTiao LuoDayou MaSuyou LiuZhiyong Luo

Published in: Cancers (2023)

We conclude that the novel isoxazoloquinone ZSW may be developed as a cancer therapeutic because it targets STAT3, thereby inhibiting the stemness of cancer cells.

Keyphrases

papillary thyroid
cell proliferation
stem cells
signaling pathway
epithelial mesenchymal transition
squamous cell
small molecule
lymph node metastasis
childhood cancer