Shuangdong Capsule Activates Insulin Signal Pathway to Improve Urinary Tract Infection in Diabetic Rats.

Cong Zhao Bin Wang Qi-Xiang Mu Jun Wu Zhen-Han Cheng Qing Liu Hai-Song Li Ji-Sheng Wang

Published in: Combinatorial chemistry & high throughput screening (2024)

The Shuangdong capsule was effective in treating diabetes with UTIs. It may function by activating the IRS1-PI3K-Akt signaling pathway, thereby increasing CXCL2 and MPO levels, enhancing innate immunity, and promoting bacterial clearance. The Mendelian randomization study provided further evidence supporting the causal role of the insulin receptor in UTI prevention.

Keyphrases

signaling pathway
pi k akt
urinary tract infection
type diabetes
diabetic rats
glycemic control
cell cycle arrest
oxidative stress
induced apoptosis
epithelial mesenchymal transition
cell proliferation
cardiovascular disease
insulin resistance
adipose tissue
weight loss