Depleting PTOV1 sensitizes non-small cell lung cancer cells to chemotherapy through attenuating cancer stem cell traits.
Zhiqiang WuZhuang LiuXiangli JiangZeyun MiMaobin MengHui WangJinlin ZhaoBoyu ZhengZhiyong YuanPublished in: Journal of experimental & clinical cancer research : CR (2019)
These results suggest that PTOV1 plays an important role in the development and progression of human NSCLC and PTOV1 may serve as a therapeutic target for NSCLC patients.
Keyphrases
- small cell lung cancer
- end stage renal disease
- cancer stem cells
- endothelial cells
- ejection fraction
- advanced non small cell lung cancer
- chronic kidney disease
- newly diagnosed
- prognostic factors
- single cell
- cell therapy
- stem cells
- squamous cell carcinoma
- gene expression
- dna methylation
- oxidative stress
- brain metastases
- radiation therapy
- mesenchymal stem cells
- induced pluripotent stem cells
- tyrosine kinase
- patient reported
- endoplasmic reticulum stress
- rectal cancer