Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge.
Fernando BartolomeDesiree AntequeraMacarena de la CuevaMarcos Rubio-FernandezNerea CastroConsuelo PascualAntoni CaminsEva CarroPublished in: Journal of neuroinflammation (2020)
We propose a protective role for megalin on diet-induce obesity, suggesting this could be related to metabolic disturbances found in dementia through brain endocrine system communications.
Keyphrases
- high fat diet
- insulin resistance
- high fat diet induced
- weight loss
- resting state
- adipose tissue
- white matter
- metabolic syndrome
- type diabetes
- functional connectivity
- mild cognitive impairment
- skeletal muscle
- endothelial cells
- physical activity
- cerebral ischemia
- weight gain
- cognitive impairment
- multiple sclerosis
- smoking cessation
- brain injury
- wild type