High-fat diet-induced diabetes leads to vascular alterations, pericyte reduction, and perivascular depletion of microglia in a 6-OHDA toxin model of Parkinson disease.
Osama F ElabiJoão Paulo M C M CunhaAbderahim GacebMalin FexGesine PaulPublished in: Journal of neuroinflammation (2021)
This study provides the first evidence for an interaction of DMT2 and PD at the brain microvasculature involving changes in the interaction of microglia with microvessels. These pathological changes may contribute to the pathological mechanisms underlying the accelerated progression of PD when associated with diabetes.
Keyphrases
- parkinson disease
- high fat diet induced
- type diabetes
- deep brain stimulation
- cardiovascular disease
- insulin resistance
- glycemic control
- inflammatory response
- neuropathic pain
- escherichia coli
- blood brain barrier
- white matter
- metabolic syndrome
- adipose tissue
- spinal cord
- spinal cord injury
- weight loss
- cerebral ischemia