Supercharging and multiple reaction monitoring of high-molecular-weight intact proteins using triple quadrupole mass spectrometry.
Durga D KhanalYehia Z BaghdadyBenjamin J FigardKevin A SchugPublished in: Rapid communications in mass spectrometry : RCM (2019)
The feasibility for top-down quantitative analysis of high-molecular-weight proteins with a triple quadrupole mass spectrometer was demonstrated. Further, additives such as TFE can be highly beneficial for increased chargeability and response of the proteins.