Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma.

Hiroki IshiiTakahiro TsujikawaNaoki OishiArisa KinouchiKaname SakamotoJunichi MitsudaHiroshi OgiKyoko ItohTetsuo KondoShigeru HiranoDaiju Sakurai

Published in: Clinical case reports (2022)

Metastatic intrathyroid thymic carcinoma (ITTC) is a rare cancer with no effective drugs for controlling. This case report has shown genomic and immune microenvironment profiles in metastatic ITTC and emphasized an immunosuppression via a PD-1/PD-L1 pathway, possibly strengthening the rationale for immune checkpoint blockade as a novel treatment.

Keyphrases

squamous cell carcinoma
small cell lung cancer
case report
stem cells
copy number
papillary thyroid
clinical trial
young adults
dna methylation
squamous cell
childhood cancer