Biased receptor signalling and intracellular trafficking profiles of structurally distinct formylpeptide receptor 2 agonists.
Cheng PengElizabeth A VecchioAnh T N NguyenMia De SeramRuby TangPeter KeovOwen L WoodmanYung-Chih ChenJonathan BaellLauren T MayPeishen ZhaoRebecca Helen RitchieChengxue Helena QinPublished in: British journal of pharmacology (2024)
In vitro characterisation demonstrated that WKYMVm and ACT-389949 differ from BMS-986235 and compound 43 in their signalling and protein coupling profile. This observation may be explained by differences in the ligand-receptor interactions. In vitro characterisation provided significant insights into identifying the desired bias profile for FPR2-based pharmacotherapy.