miR-1 is a novel biomarker for polymyositis/dermatomyositis-associated interstitial lung disease.
Yumiko SugiyamaRyusuke YoshimiMitsuhiro TakenoYosuke KunishitaDaiga KishimotoReikou KamiyamaYohei KirinoShigeru OhnoHideaki NakajimaPublished in: Modern rheumatology (2019)
Objectives: Although intensive immunosuppressive treatment is necessary for the severe cases with polymyositis (PM)/dermatomyositis (DM), the prognostic factors or disease activity indices for PM/DM have not been established. Here we investigated the association between serum microRNA-1 (miR-1) level and clinical course of patients with PM/DM.Methods: We retrospectively reviewed baseline clinical and laboratory findings, treatment regimens and outcomes in patients with PM/DM. The serum samples were collected from PM/DM patients and healthy controls (HC). Serum miR-1 levels were determined by quantitative real-time PCR.Results: Twenty-two patients were recruited. The average serum miR-1 level was significantly higher in the PM/DM as compared to HC (p = .0085) and was decreased by treatment (p = .032). We divided the PM/DM-ILD patients into two groups, high and normal miR-1 groups. Although there were no significant differences in the clinical data and the initial prednisolone (PSL) dose between the two groups, PSL dose at 16 weeks, cumulative PSL dose until 16 weeks, and frequency of serious infections were significantly higher in the high miR-1 group as compared to the normal group (p = .025, .036, and .026, respectively).Conclusion: We propose serum miR-1 as a promising novel biomarker for predicting therapeutic response in PM/DM-ILD.
Keyphrases
- interstitial lung disease
- cell proliferation
- particulate matter
- prognostic factors
- long non coding rna
- air pollution
- end stage renal disease
- systemic sclerosis
- long noncoding rna
- disease activity
- polycyclic aromatic hydrocarbons
- rheumatoid arthritis
- heavy metals
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- idiopathic pulmonary fibrosis
- systemic lupus erythematosus
- water soluble
- high resolution
- early onset
- skeletal muscle
- machine learning
- adipose tissue
- replacement therapy