The formation of multiple pituitary pouches from the oral ectoderm causes ectopic lens development in hedgehog signaling-defective avian embryos.
Yuki TairaYuya IkutaSachiko InamoriMitsuo NunomeMikiharu NakanoTakayuki SuzukiYoichi MatsudaMasaoki TsudzukiMachiko TeramotoHideaki IidaHisato KondohPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2020)
Hedgehog signaling in normal embryos regulates the development of Rathke's pouch in two steps. First, by confining Rathke's pouch development in a low hedgehog signaling region of the OE. Second, by sustaining LHX3 activity to promote anterior pituitary development, while inhibiting ectopic lens development.
Keyphrases