BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1/M2 macrophage polarization in rats.

Zhenyu LiQingxian LiKai TongJiayong ZhuHui WangBiao ChenLiaobin Chen

Published in: Stem cell research & therapy (2022)

BMSC-Exos promoted M1 macrophage to M2 macrophage polarization via miR-23a-3p, reduced the early inflammatory reaction at the tendon-bone interface, and promoted early healing after ACLR.

Keyphrases

anterior cruciate ligament reconstruction
bone mineral density
mesenchymal stem cells
soft tissue
bone loss
oxidative stress
postmenopausal women
rotator cuff
bone marrow