Inflammatory bowel disease in chronic granulomatous disease: An emerging problem over a twenty years' experience.
Giulia AngelinoPaola De AngelisSimona FaraciFrancesca ReaErminia Francesca RomeoFilippo TorroniRenato TambucciAlessia ClapsPaola FrancalanciMaria ChiriacoGigliola Di MatteoCaterina CancriniPaolo PalmaPatrizia D'ArgenioLuigi Dall'OglioPaolo RossiAndrea FinocchiPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2018)
Penetrance of CGD-IBD increases with age. Clinical manifestations may be subtle, and clinicians should have a low threshold to recommend endoscopy. Treatment with NSAIDs and/or steroids achieves a good response, but relapses usually occur. Infection surveillance is mandatory during treatment, to prevent opportunistic infections. A close collaboration between pediatric immunologists and gastroenterologists is pivotal, including combined follow-up.