Further evidence for deletions in 7p14.1 contributing to nonsyndromic cleft lip with or without cleft palate.

Johanna KlamtAndrea HofmannAnne C BöhmerAnn-Kathrin HoebelLina GölzJessica BeckerAlexander M ZinkMarkus DraakenAlexander HemprichMartin ScheerGül SchmidtMarkus MartiniMichael KnappElisabeth MangoldFranziska DegenhardtKerstin U Ludwig

Published in: Birth defects research. Part A, Clinical and molecular teratology (2016)

The present data support the hypothesis that deletions at 7p14 are a common risk factor for nsCL/P. Genome-wide CNV analyses in nsCL/P cohorts are warranted to explore the functional relevance of these deletions and their contribution to nsCL/P, and to determine exact breakpoints. Birth Defects Research (Part A) 106:767-772, 2016. © 2016 Wiley Periodicals, Inc.

Keyphrases

genome wide
dna methylation
electronic health record
density functional theory
gene expression
artificial intelligence
data analysis