Unraveling Autonomic Dysfunction in GBA-Related Parkinson's Disease.

Grazia DevigiliGiulia StracciaEmanuele CeredaBarbara GaravagliaAlessandro FedeliAntonio Emanuele EliaSylvie Hélène Marie Jeanne PiacentiniSara PrioniPaolo AmamiFederica InvernizziNico Golfrè AndreasiLuigi Michele RomitoRoberto EleopraRoberto Cilia

Published in: Movement disorders clinical practice (2023)

Compared to PD noncarriers, GBA-PD display more severe instrumental autonomic abnormalities, which may be underestimated by purely clinical measures, despite their relevance on morbidity and mortality. This supports the necessity of implementing instrumental autonomic assessment in all GBA-PD, regardless of clinically overt symptoms.

Keyphrases

heart rate variability
heart rate
oxidative stress
early onset
blood pressure
drug induced
physical activity
depressive symptoms
sleep quality