Heritability of circle of Willis variations in families with intracranial aneurysms.
Mayte Sánchez van KammenCharles J MoomawIrene C van der SchaafRobert D BrownDaniel WooJoseph P BroderickJason S MackeyGabriël J E RinkelJohn HustonYnte M RuigrokPublished in: PloS one (2018)
In two independent groups of families with familial aneurysms, the incomplete PcomA variation occurred more often within than between families suggesting heritability of this circle of Willis variation. Further studies should investigate genetic variants associated with circle of Willis formation.