Natural history and outcomes in paediatric RASopathy-associated hypertrophic cardiomyopathy.
Olga BoletiGabrielle NorrishElla FieldKathleen DadyKim SummersGauri NepaliVinay BholeOrhan UzunAmos WongPiers E F DaubeneyGraham StuartPrecylia FernandesKaren McLeodMaria IlinaMuhammad Najih Liaqath AliTara BharuchaGrazia Delle DonneElspeth BrownKatie LinterCaroline B JonesJonathan SearleWilliam ReganSujeev MathurNicola BoydZdenka ReinhardtSophie DuignanTerence PrendivilleSatish AdwaniJuan Pablo KaskiPublished in: ESC heart failure (2024)
These findings highlight a distinct category of patients with Noonan-like syndrome with a milder HCM phenotype but significantly worse survival and identify potential predictors of adverse outcome in patients with RASopathy-related HCM.