Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats.

Hui LiangNathanael MateiDevin W McBrideYang XuJiping TangBen-Yan LuoJohn H Zhang

Published in: Journal of biomedical science (2020)

Our findings demonstrate that activating TGR5 could reduce BBB breakdown and improve neurological functions through BRCA1/Sirt1 signaling pathway after MCAO. TGR5 may serve as a potential new candidate to relieve brain injury after MCAO.

Keyphrases

blood brain barrier
brain injury
middle cerebral artery
cerebral ischemia
signaling pathway
subarachnoid hemorrhage
internal carotid artery
oxidative stress
ischemia reperfusion injury
pi k akt
epithelial mesenchymal transition
induced apoptosis
breast cancer risk
cell proliferation